Biogenesis of Multilamellar Bodies via Autophagy
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چکیده
منابع مشابه
Biogenesis of multilamellar bodies via autophagy.
Transfection of Mv1Lu mink lung type II alveolar cells with beta1-6-N-acetylglucosaminyl transferase V is associated with the expression of large lysosomal vacuoles, which are immunofluorescently labeled for the lysosomal glycoprotein lysosomal-associated membrane protein-2 and the beta1-6-branched N-glycan-specific lectin phaseolis vulgaris leucoagglutinin. By electron microscopy, the vacuoles...
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Vesicle-like structures containing several to numerous concentric membranes, called multilamellar bodies (MLBs), are present both in animal and plant cells. The origin of MLBs in animal cells has been elucidated partially, while that of plant MLBs is unknown. MLBs in plant cells are present in the cytoplasm, at the interface of cytoplasm and vacuole, and inside vacuoles. 5 This suggests that th...
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Multilamellar bodies (MLBs) are responsible for surfactant secretion in type II alveolar cells but also accumulate in other cell types under pathological conditions, including cancer and lysosomal storage diseases such as Niemann-Pick C (NPC), a congenital disease where defective cholesterol transport leads to its accumulation in lysosomes. Mv1Lu type II alveolar cells transfected with Golgi be...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2000
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.11.1.255